Modulation of immune responses by DNA damage signaling

An accumulation of evidence indicates the importance DNA damage signaling in modulating immune responses. Indeed, understanding mechanism that underlies signal transduction originating from is vital to overcoming refractory cancer, particularly when cancer therapy applied combination with damage-dependent radio/chemotherapy. In addition, immune-associated responses such signals can aggravate symptoms infections, allergies, autoimmune disease, and aging. this review, we discuss how cells transduce signals, triggered by damage, their origins neighboring affects inflammatory